JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer

  • 0Neufeld and Tamman Cardiovascular Research Institutes, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Jacc. Cardiooncology +

|

January 13, 2025

|

January 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Atherosclerotic cardiovascular disease (ASCVD) is linked to a higher risk of cancer metastasis at diagnosis, especially in middle-aged individuals. This finding may improve prevention and treatment strategies for metastatic cancer in ASCVD patients.

Area Of Science

  • Cardiovascular research
  • Oncology
  • Epidemiology

Background

  • Cardiovascular diseases (CVD) are known risk factors for cancer.
  • The specific relationship between CVD and metastatic cancer, a key prognostic factor, remains understudied.

Purpose Of The Study

  • To investigate the association between atherosclerotic cardiovascular disease (ASCVD) and the presence of metastasis at cancer diagnosis.
  • To explore age-related differences in this association.

Main Methods

  • Analysis of data from 21,654 adults initially free of cancer and ASCVD.
  • A 1-year blanking period was used to exclude prevalent cancers.
  • Cause-specific Cox regression with time-dependent covariates assessed the ASCVD-metastasis link.
  • Interaction analysis examined age-group differences (≤54 vs. >54 years).

Main Results

  • Over a median 6-year follow-up, ASCVD was diagnosed in 6.2% and cancer in 8.3% of participants.
  • ASCVD was independently associated with an increased risk of cancer metastasis at diagnosis (HR: 1.75).
  • This association was stronger in middle-aged adults (HR: 1.64, P=0.036) than older adults (HR: 1.11, P=0.56), with significant interaction (P=0.039).

Conclusions

  • ASCVD is significantly associated with an elevated risk of cancer metastasis at diagnosis.
  • This risk is particularly pronounced in middle-aged adults.
  • Identifying this link can aid in preventing and managing metastatic cancer in individuals with ASCVD.

Keywords:

Related Concept Videos

Metastasis 02:30

5.5K

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

Cancer Prevention 02:59

6.0K

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...

Psychoneuroimmunology: Diabetes and Cancer 01:19

22

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

Cardiovascular Drugs: Classification based on Therapeutic Indications 01:18

2.0K

Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...

Cancer Survival Analysis 01:21

328

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Skin Cancer 01:30

3.1K

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...