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Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...

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Development and Validation of a Computational Histology Artificial Intelligence-Powered Biomarker in Metastatic Hormone-Sensitive Prostate Cancer on Randomized Phase III Trials.

JCO precision oncology·2026
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Clinically relevant endpoints and quality-of-life outcomes with darolutamide in patients with metastatic hormone-sensitive prostate cancer: Analyses of the phase III ARASENS trial.

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Bone-Modifying Agents in Metastatic Castration-Resistant Prostate Cancer.

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Cardiovascular Risk in Prostate Cancer: JACC: CardioOncology State-of-the-Art Review.

Darryl P Leong1, Avirup Guha2,3, Alicia K Morgans4

  • 1Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.

JACC. Cardiooncology
|January 13, 2025
PubMed
Summary

Patients with prostate cancer often have cardiovascular disease, a leading cause of death. Treatments like androgen deprivation therapy may increase cardiovascular risks, necessitating further research into safer treatment options.

Keywords:
androgen deprivation therapycardio-oncologycardiovascular diseaseprostate cancerrisk factors

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Area of Science:

  • Oncology
  • Cardiology
  • Endocrinology

Background:

  • Cardiovascular disease (CVD) is highly prevalent in prostate cancer (PC) patients and a major cause of mortality.
  • Common cardiovascular risk factors are often undertreated in PC patients, deviating from clinical guidelines.
  • Androgen deprivation therapy (ADT) is associated with adverse metabolic changes, potentially increasing risks for diabetes and hypertension, but its direct link to cardiovascular events needs further investigation.

Purpose of the Study:

  • To investigate the cardiovascular risks associated with ADT and its related therapies in prostate cancer patients.
  • To evaluate the impact of androgen receptor pathway inhibitors on hypertension and cardiovascular events.
  • To compare the cardiovascular risk profiles of gonadotropin-releasing hormone (GnRH) antagonists versus agonists.

Main Methods:

  • Review of existing literature and clinical data on cardiovascular outcomes in prostate cancer patients undergoing ADT.
  • Analysis of the risks conferred by androgen receptor antagonists and CYP17A1 inhibitors.
  • Assessment of cardiovascular event rates in patients treated with GnRH antagonists versus agonists.

Main Results:

  • ADT is linked to increased adiposity and risk of diabetes and hypertension.
  • Androgen receptor pathway inhibitors (antagonists and CYP17A1 inhibitors) appear to add to the cardiovascular risks of ADT.
  • Evidence suggests a potentially lower cardiovascular risk with GnRH antagonists compared to agonists, though this requires further confirmation.

Conclusions:

  • Cardiovascular health is a critical concern for prostate cancer patients, particularly those on ADT.
  • Androgen-targeting therapies, including newer agents, may increase cardiovascular and hypertensive risks.
  • Further robust clinical trials are essential to confirm the comparative cardiovascular safety of different ADT strategies, especially GnRH antagonists versus agonists.