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Published on: October 16, 2013
Diverticulosis and neoplastic lesions in screening colonoscopy: a large, multicenter study
Paolo Fedeli1, Monica Masotti1, Chiara Marzano2
1Gastroenterology Unit, Santo Spirito in Sassia Hospital, Rome (Paolo Fedeli, Monica Masotti).
This study found no significant link between diverticulosis and colorectal cancer or adenomas in individuals undergoing screening colonoscopy. Further research is needed to clarify the relationship between diverticular disease and colon neoplasia.
Area of Science:
- Gastroenterology
- Oncology
- Preventive Medicine
Background:
- The association between diverticulosis and colonic neoplastic lesions remains controversial.
- Screening colonoscopy data provides an opportunity to investigate this relationship.
Purpose of the Study:
- To investigate the association between diverticulosis and colonic neoplastic lesions.
- To analyze data from subjects undergoing screening colonoscopy.
Main Methods:
- Retrospective review of colonoscopy data from 5050 subjects.
- Univariate and multivariate analyses were performed.
- Evaluation of endoscopic and histological reports for diverticula, adenomas, advanced adenomas, and cancer.
Main Results:
- Diverticula were present in 43.1% of subjects.
- Adenomas were detected in 45.1%, advanced adenomas in 16.7%, and cancer in 3.1%.
- Multivariate analysis identified male sex and age as independent predictors of neoplastic lesions, but not diverticulosis.
Conclusions:
- This large, multicenter study found no significant association between diverticulosis and neoplastic lesions.
- Diverticulosis was not an independent predictor of adenomas, advanced adenomas, or cancer in this screening population.
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