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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

480
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Related Experiment Video

Updated: Jun 3, 2025

Routine Screening Method for Microparticles in Platelet Transfusions
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Published on: January 31, 2018

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A standards-based application for improving platelet transfusion workflow.

William Gordon1,2,3, Maria Aguad4, Layne Ainsworth3

  • 1Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States of America.

Journal of Pathology Informatics
|January 13, 2025
PubMed
Summary
This summary is machine-generated.

A new electronic health record-integrated application was developed to improve platelet matching for patients with thrombocytopenia undergoing hematopoietic stem-cell transplantation (HSCT). The application did not significantly reduce complicated thrombocytopenia courses in the study cohort.

Keywords:
Clinical innovationHLAInteroperabilityPathology informaticsPlatelet transfusion

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Area of Science:

  • Hematology
  • Transplantation Medicine
  • Health Informatics

Background:

  • Thrombocytopenia is a frequent complication of hematopoietic stem-cell transplantation (HSCT).
  • Patients undergoing HSCT often develop immune refractoriness to platelet transfusions.
  • Current methods may not fully optimize platelet inventory matching for these complex patients.

Purpose of the Study:

  • To develop and evaluate an electronic health record (EHR)-integrated application for improved platelet transfusion management.
  • To leverage previously unavailable data, such as human leukocyte antigen (HLA) matching, at the point-of-care.
  • To assess the impact of the application on the incidence of complicated thrombocytopenia courses in HSCT patients.

Main Methods:

  • A web-based, EHR-integrated application was developed to unify disparate data streams, including platelet counts, HLA data, demographics, and real-time inventory.
  • A multivariable logistic regression model was used to analyze patient data (n=376) and assess the odds of a complicated thrombocytopenia course.
  • Covariates included pre- and post-application deployment status, alongside other relevant clinical factors.

Main Results:

  • The application demonstrated consistent usage post-launch, with a minor decrease during the initial COVID-19 wave.
  • The logistic regression model, analyzing 376 patients, did not find a statistically significant reduction in the odds of a complicated thrombocytopenia course after the application's deployment compared to before.
  • The application successfully integrated disparate data sources into a unified view for blood bank clinicians.

Conclusions:

  • An EHR-integrated application was successfully developed and implemented into standard blood bank operating procedures to enhance platelet transfusion processes.
  • While the primary outcome of reduced complicated thrombocytopenia courses was not met in this analysis, the application offers potential workflow and clinical benefits.
  • Future evaluations are warranted to fully assess the broader clinical and operational advantages of the developed system.