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Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects

  • 0The First School of Clinical Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, People's Republic of China.
Journal of Inflammation Research +

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January 13, 2025

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January 13, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Ginkgetin protects heart cells after myocardial infarction (MI) by reducing damage and inflammation. This study shows ginkgetin’s potential as a cardioprotective agent for treating heart attacks.

Area Of Science

  • Cardiovascular Research
  • Pharmacology
  • Molecular Biology

Background

  • Myocardial infarction (MI) is a leading cause of death globally, necessitating novel cardioprotective strategies.
  • Current treatments aim to minimize cardiomyocyte damage, but more effective agents are needed.
  • Ginkgo biloba extract is recognized for treating vascular and neurological conditions.

Purpose Of The Study

  • To investigate the cardioprotective effects and underlying mechanisms of ginkgetin in post-myocardial infarction (MI) cardiomyocytes.
  • To validate bioinformatics predictions through experimental studies.

Main Methods

  • Bioinformatics analysis to predict ginkgetin's targets and pathways in MI.
  • In vivo studies using a rat model of MI induced by coronary ligation.
  • In vitro studies using H9c2 cardiomyocytes subjected to oxygen and glucose deprivation (OGD) to simulate ischemia.

Main Results

  • Bioinformatics identified MMP2, MMP9, and VEGFA as key targets; ginkgetin may regulate immunity via the TCR signaling pathway.
  • Ginkgetin ameliorated myocardial damage, cardiac dysfunction, and senescent apoptosis in vivo.
  • In vitro, ginkgetin reduced OGD-induced cytotoxicity and enhanced cardiomyocyte viability.

Conclusions

  • Ginkgetin demonstrates significant cardioprotective effects by inhibiting myocardial fibrosis, hypertrophy, and inflammation post-MI.
  • It scavenges free radicals, suppresses inflammatory pathways, and delays cardiomyocyte senescence.
  • Ginkgetin offers a promising therapeutic approach for protecting the heart after myocardial infarction.

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