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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Updated: Jun 3, 2025

Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
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Endothelin-based markers for endothelial dysfunction in chemotherapy-induced cardiotoxicity.

Gabrielle Boutin1, Jale Yuzugulen2, Md Zahidul Islam Pranjol1

  • 1School of Life Sciences, University of Sussex, Brighton, UK.

Journal of Molecular and Cellular Cardiology Plus
|January 13, 2025
PubMed
Summary

Current cardiac biomarkers lack early predictive value for chemotherapy-induced cardiotoxicity. This review explores endothelin-1 (ET-1) and its peptide fragments (ELDP, CT-proET-1) as promising biomarkers for early detection of endothelial dysfunction and cardiotoxicity.

Keywords:
BiomarkersCardiotoxicityEndothelial dysfunctionEndothelin-1Endothelin-like domain peptide

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Area of Science:

  • Cardiology
  • Oncology
  • Biomarker Discovery

Background:

  • Current cardiac biomarkers like troponins and brain natriuretic peptide have limitations in predicting chemotherapy-induced cardiotoxicity.
  • Existing biomarkers do not offer early predictive value, leading to irreversible cardiac injury in cancer survivors.
  • Endothelial dysfunction assessment is crucial for early detection of cardiotoxicity at the vascular level.

Purpose of the Study:

  • To review current blood-based cardiac biomarkers.
  • To discuss the potential of endothelin-1 (ET-1) and its peptide fragments as biomarkers for endothelial dysfunction.
  • To explore ET-1, endothelin-like domain peptide (ELDP), and C-terminal pro-endothelin-1 (CT-proET-1) as prospective predictive biomarkers for chemotherapy-induced cardiotoxicity.

Main Methods:

  • Literature review of current cardiac biomarkers.
  • Analysis of studies evaluating troponins and brain natriuretic peptide in cardiotoxicity.
  • Discussion of endothelin-1 (ET-1) and its related peptides (ELDP, CT-proET-1) for endothelial dysfunction and cardiotoxicity prediction.

Main Results:

  • Endothelin-1 (ET-1) and its stable peptide fragments, ELDP and CT-proET-1, show potential as sensitive biomarkers.
  • ELDP and CT-proET-1 possess higher sensitivity and longer clearance rates compared to ET-1.
  • These biomarkers may offer earlier prognostic value for detecting cardiotoxicity.

Conclusions:

  • Endothelin-1 (ET-1) and its peptide fragments (ELDP, CT-proET-1) are promising for early detection of chemotherapy-induced cardiotoxicity.
  • Further research is needed to fully understand ELDP's role in vasoconstriction and its clinical application.
  • These biomarkers could aid in identifying at-risk patients and preventing chronic cardiotoxicities.