Acute Niclofolan Intoxication Led to Stillbirth: A Case Report

Area of Science:

• Veterinary Pharmacology
• Toxicology
• Reproductive Medicine

Background:

• Niclofolan is a widely used veterinary anthelmintic.
• Accidental or intentional exposure can lead to human intoxication.
• Reproductive toxicity in humans has not been previously documented.

Observation:

• A pregnant woman presented with acute niclofolan intoxication.
• Symptoms included nausea, vomiting, asthenia, blurred vision, and abnormal blood work.
• Stillbirth occurred, representing a novel finding in human niclofolan toxicity.

Findings:

• The patient's symptoms were consistent with niclofolan poisoning.
• A therapeutic oral dosage, as per veterinary literature, was implicated in the stillbirth.
• Aggressive treatment, including critical care and plasma exchange, resulted in patient recovery.

Implications:

• This case underscores the potential human reproductive toxicity of niclofolan.
• It emphasizes the need for increased awareness of veterinary drug risks in pregnant individuals.
• Highlights the importance of recognizing and managing niclofolan intoxication, and addresses concerns of veterinary drug misuse.