Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.4K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
8.6K
Pleiotropy01:33

Pleiotropy

39.6K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
39.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Hippocampal Cellular Pathologies Influence Cognition Across Diagnostic Categories, Also Distinguishing Schizophrenia from Affective Psychoses.

bioRxiv : the preprint server for biology·2026
Same author

Dual-DNA nanoball-mediated 3D catalytic hairpin assembly for in situ imaging of miRNA-155 in living cells.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Bacterial topography of the respiratory tract, including pulmonary site-of-disease, in people with active tuberculosis: a case-control study.

Research square·2026
Same author

Power and sample-size estimation in human microbiome research.

Med (New York, N.Y.)·2026
Same author

Do Symptom Domains Have Similar Cellular Underpinnings Across Psychiatric Diagnoses: Evidence from 3D Hippocampal MR Spectroscopy.

bioRxiv : the preprint server for biology·2026
Same author

Gut microbial IgA coating in infants with traditional farming lifestyle and urban infants with allergic outcomes.

Frontiers in immunology·2026

Related Experiment Video

Updated: Jun 3, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K

Multi-omic Biomarkers Distinguish Rheumatoid Arthritis in Discordant Monozygotic Twins.

Rebecca B Blank1, Kevin Bu2, Weixi Chen3

  • 1Division of Rheumatology, NYU School of Medicine.

Medrxiv : the Preprint Server for Health Sciences
|January 13, 2025
PubMed
Summary

Identical twins with rheumatoid arthritis (RA) showed decreased levels of the gut bacterium Blautia faecis and beneficial short-chain fatty acids. These multi-omics biomarkers may help understand RA development and inform new therapies.

More Related Videos

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

12.8K
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.4K

Related Experiment Videos

Last Updated: Jun 3, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.1K
Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies
10:16

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

12.8K
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.4K

Area of Science:

  • Immunology
  • Microbiome research
  • Genetics

Background:

  • Rheumatoid arthritis (RA) pathogenesis involves genetic factors, but low concordance in identical twins suggests non-genetic influences.
  • The specific non-genetic factors contributing to RA in genetically identical individuals remain poorly characterized.

Purpose of the Study:

  • To identify differentiating host and microbial biomarkers in monozygotic (MZ) twins discordant for rheumatoid arthritis (RA).
  • To investigate the role of non-genetic factors in RA development using a multi-omics approach in MZ twins.

Main Methods:

  • Studied eight pairs of MZ twins discordant for RA.
  • Assessed gut microbiome via shotgun metagenomic sequencing.
  • Measured autoantibodies, cytokines, plasma proteins, and short-chain fatty acids (SCFAs) in serum and feces using GC-MS.

Main Results:

  • No significant differences in overall microbiome diversity or composition between twins.
  • Decreased levels of Blautia faecis observed in RA-affected twins.
  • Elevated autoantibodies and reduced fecal butyrate and propionate (SCFAs) found in affected twins.

Conclusions:

  • Multi-omics analysis revealed distinct biomarkers differentiating MZ twins with and without RA.
  • Reduced Blautia faecis and SCFAs in RA twins suggest gut barrier inflammation interactions.
  • Findings may enhance understanding of RA pathogenesis and inform novel diagnostic and therapeutic strategies.