Beyond Boundaries: Breast Cancer Metastasizing to Colon-An Insight into a Rare yet Significant Clinical Scenario: A...

Area of Science:

• Oncology
• Gastroenterology
• Pathology

Background:

• Colorectal metastasis from primary breast cancer is an uncommon occurrence.
• Invasive lobular breast carcinoma (ILBC) metastasis to the colon presents diagnostic and therapeutic challenges.
• This case series reviews two distinct presentations of colorectal metastasis from ILBC.

Observation:

• Case 1: A 47-year-old female with a history of bilateral ILBC presented 8 years post-mastectomy with abdominal pain and altered bowel habits, diagnosed with metastatic ILBC to the colon.
• Case 2: A 52-year-old female presented with constipation, weight loss, and abdominal pain, diagnosed with primary invasive lobular carcinoma (ILC) of the breast with rectal metastasis.

Findings:

• Both cases highlight varied clinical presentations of colorectal metastasis from ILBC.
• Histopathology and immunohistochemistry confirmed metastatic ILBC in both patients.
• Diagnosis involved colonoscopy, biopsy, and advanced imaging like PET-CT.

Implications:

• Increased incidence of colorectal metastasis from ILBC necessitates heightened awareness and research.
• Early detection strategies and multidisciplinary treatment approaches are vital for improving prognosis.
• Further research is needed to enhance understanding and management of gastrointestinal metastases from breast cancer.