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Updated: Jun 2, 2025

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Unusual Presentation of Hyperandrogenism in Postmenopausal Women: A Report of Two Patients With Leydig Cell
Frederik Duhamel1, David Unuane1,2, Stefanie Brock3
1Endocrine and Diabetes Unit, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, BEL.
Abstract:
Hyperandrogenism is a highly prevalent and debilitating hormonal disturbance encountered in women presenting with variable phenotypical features. Causes encompass a large spectrum of tumoral and nontumoral etiologies, depending on the patients' age. We report two postmenopausal patients with an unusual etiology of hyperandrogenism. Both underwent salpingo-oophorectomy. While the first patient was cured after bilateral salpingo-oophorectomy, the second patient had residual disease after unilateral surgical management. Complete disease control was achieved after the adjunction of medical treatment. This report emphasizes the indication of bilateral salpingo-oophorectomy for the management of hyperandrogenism in postmenopausal women. A better understanding of the added value of presurgical hormonal status in further characterization of the disease phenotype is needed.
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