Comparative Investigation of the Nutritional Profiling and Antipyretic Activity of Moringa oleifera Leaves, Bark, and Root From Different Sites of Punjab, Pakistan

Shaista Jamil ¹, Tanveer Hussain Turabi ¹, Saeed Ahmad ²

⁰Institute of Forest Sciences, Faculty of Agriculture and Environment The Islamia University of Bahawalpur Bahawalpur Pakistan.

Food Science & Nutrition +

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January 13, 2025

View abstract on PubMed

Summary

Moringa oleifera leaves, bark, and root extracts were studied for nutritional and antipyretic properties. Leaf extracts from Southern Punjab showed the best results, indicating potential as a traditional fever treatment.

Area Of Science

Pharmacology
Ethnobotany
Nutritional Science

Background

Moringa oleifera is widely recognized for its medicinal and nutritional value.
Research is ongoing to explore various plant parts for human and animal benefits.
Traditional medicine often utilizes Moringa for its therapeutic properties.

Purpose Of The Study

To conduct a proximate analysis and evaluate the antipyretic activity of methanolic extracts from Moringa oleifera leaves, bark, and root.
To compare the efficacy of extracts from different regions of Punjab, Pakistan.
To validate the traditional use of Moringa oleifera in fever management.

Main Methods

Methanolic extracts of M. oleifera leaves, bark, and root were prepared from three distinct regions in Punjab, Pakistan (S1, S2, S3).
Proximate analysis was performed to determine nutritional composition.
Antipyretic activity was assessed using baker's yeast-induced pyrexia in animal models, with paracetamol as a reference drug.
Statistical analysis included one-way ANOVA and Tukey's post hoc test (p < 0.05).

Main Results

All M. oleifera extracts exhibited statistically significant antipyretic effects at doses of 50, 100, and 150 mg/kg body weight.
The methanolic extract from S1 (Southern Punjab) leaves demonstrated superior proximate composition and the most potent antipyretic activity compared to other extracts.
M. oleifera leaves showed higher antipyretic activity than bark and root extracts.

Conclusions

The methanolic extract of Moringa oleifera leaves possesses significant antipyretic properties.
The findings support the traditional use of M. oleifera leaves as a nutritional supplement and in the treatment of fever.
Regional variations in M. oleifera may influence its phytochemical profile and medicinal efficacy.

Keywords:

Moringa oleifera antipyretic activity proximate analysis