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Molecular Characterization and Risk Factors of Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae Isolated from

Rongping Zhu1,2, Ju Li1, Siyan Lian1

  • 1Department of Laboratory Medicine, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, People's Republic of China.

Infection and Drug Resistance
|January 13, 2025
PubMed
Abstract

Insights

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp), predominantly K64 strains, were identified. Changing patient beds emerged as a significant risk factor for CR-hvKp infection, informing prevention strategies.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) poses a significant threat.
  • Understanding CR-hvKp prevalence and characteristics is crucial for effective control.

Purpose of the Study:

  • Investigate CR-hvKp prevalence in Fujian Medical University Union Hospital.
  • Identify genetic traits, resistance profiles, and infection risk factors.
  • Inform local prevention and treatment strategies.

Main Methods:

  • Collected and analyzed 239 carbapenem-resistant Klebsiella pneumoniae isolates.
  • Utilized PCR for gene detection (virulence, carbapenemase, capsule) and ERIC-PCR for genetic relatedness.
  • Performed antimicrobial susceptibility testing and logistic regression for risk factor analysis.

Main Results:

  • Identified 54 (22.59%) CR-hvKp isolates, primarily K64 serotype, all harboring blaKPC.
  • Detected high prevalence of virulence genes iucA and rmpA2.
  • Found ceftazidime-avibactam effective; identified bed changing as a risk factor.

Conclusions:

  • K64 CR-hvKp carrying blaKPC is predominant in the studied hospital.
  • Changing patient beds is an independent risk factor for CR-hvKp infection.
  • Findings guide targeted infection control measures.
Keywords:
Klebsiella pneumoniaecarbapenem-resistanthypervirulentresistancerisk factorvirulence

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