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Updated: May 4, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
A 63 year-Old Male With a Painful Subacute Demyelinating Neuropathy
Audrey Blazek Ramsay1, Kim Griffin1, Michael Skolka1
1Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Abstract:
Subacute, painful weakness is a common problem encountered by neurologists and can be associated with systemic symptoms. The patient presented with 6 weeks of progressive neuropathic pain followed by sensory changes and distal-predominant weakness. This case reviews the broad differential for such a presentation and a comprehensive, stepwise approach to diagnosis. Particular attention is paid to the potentially treatable polyradiculoneuropathies, including more recently recognized immune-mediated etiologies. Through this stepwise approach, we review how a definitive diagnosis was made.
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