Related Experiment Video

Updated: Jun 2, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.2K

P-, E-, and H-cadherins differ in their relationships with coronary stenosis, cardiovascular outcomes, and unplanned

Nadezhda G Gumanova1, Dmitry K Vasilyev1, Natalya L Bogdanova1

  • 1National Research Center for Preventive Medicine (NRCPM), Petroverigsky, 10, building 3, Moscow 101990, Russia.

Journal of Molecular and Cellular Cardiology Plus
|January 13, 2025
PubMed

Insights

High levels of P-cadherin and E-cadherin, and low levels of H-cadherin, are linked to atherosclerosis severity and cardiovascular events. These cadherins may serve as important biomarkers for assessing cardiovascular risk.

Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Cadherins are cell adhesion proteins crucial for vascular wall integrity.
  • Dysregulation of cadherins is implicated in atherosclerosis development and plaque instability.
  • Understanding cadherin roles is vital for cardiovascular disease research.

Purpose of the Study:

  • To investigate the association between serum levels of P-cadherin, E-cadherin, and H-cadherin and atherosclerosis.
  • To determine the relationship between these cadherins and pathological cardiovascular conditions.
  • To explore cadherins as potential biomarkers for cardiovascular risk assessment.

Main Methods:

  • A 3-year follow-up study involving 214 patients.
  • Serum cadherin levels (P-, E-, H-cadherin) measured by ELISA.
  • Coronary lesion severity assessed using Gensini score via coronary angiography.
  • Serum proteomic profiling using antibody microarrays.

Main Results:

  • Elevated serum P-cadherin and E-cadherin levels correlated with increased atherosclerosis severity.
  • High P-cadherin and E-cadherin levels were associated with a higher incidence of nonfatal cardiovascular outcomes.
  • E-cadherin levels predicted recurrent revascularization within the 3-year follow-up period.
  • Cadherin levels showed associations with various lipid, endothelial, and metabolic biomarkers.

Conclusions:

  • Cadherins (P-, E-, H-) are associated with atherosclerosis progression and cardiovascular risk.
  • Elevated P-cadherin specifically linked to coronary atherosclerosis.
  • Lipid, endothelial, and metabolic biomarkers may influence cadherin levels.
  • P-, E-, and H-cadherins show promise as cardiovascular risk assessment markers.
Abstract

Keywords:
Antibody microarrayAtherosclerosisCardiovascular biomarkersE-cadherinH-cadherinP-cadherin

More Related Videos

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules08:15

Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

Published on: October 17, 2014

10.5K
Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans04:40

Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans

Published on: August 28, 2018

15.1K

Related Concept Videos

Structure of Cadherins01:25

Structure of Cadherins

The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins”   is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
3.3K
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
2.9K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K