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Rare Cell Population Analysis in Early-Stage Breast Cancer Patients.

Stefan Schreier1,2,3, Prapaphan Budchart3, Suparerk Borwornpinyo3,4

  • 1School of Bioinnovation and Bio-based Product Intelligence, Faculty of Science, Mahidol University, Bangkok, Thailand.

Breast Cancer : Basic and Clinical Research
|January 13, 2025
PubMed
Summary

This study introduces a new platform for detecting rare cells in breast cancer patients, revealing abnormalities linked to systemic cancer. These findings offer new theranostic insights for early-stage disease management.

Keywords:
circulating rare cellscirculating tumor cellscytomorphologyearly-stage breast cancerliquid biopsysystemic inflammation

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Area of Science:

  • Oncology
  • Cell Biology
  • Medical Diagnostics

Background:

  • Circulating rare cells are integral to breast cancer progression and offer theranostic potential.
  • Current understanding and exploration of cancer-associated rare cells are limited.

Purpose of the Study:

  • To investigate and classify circulating rare cell abnormalities in early-stage breast cancer.
  • To determine the association of these rare cell markers with tumor presence.

Main Methods:

  • Evaluation of a multi-rare-cell detection platform (Rarmax) using fluorescence and cytomorphology.
  • Analysis of rare cell populations (including circulating tumor cells) before and after tumor resection in breast cancer patients and controls.

Main Results:

  • The Rarmax platform demonstrated linear performance and high recovery rates.
  • Specific circulating epithelial and endothelial-like cell subsets were associated with cancer presence, independent of tumor status.
  • High sensitivity and specificity were achieved in detecting tumor presence and cancer-associated abnormalities.

Conclusions:

  • Cancer-associated rare cell abnormalities can represent both tumor entities and systemic cancer.
  • This approach provides a novel method for characterizing the breast cancer system and its systemic spread.