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Related Experiment Video

Updated: Jun 2, 2025

Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
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Consensus on Symptom Selection for Endometriosis Questionnaires: A Modified e-Delphi Study.

Tong Zhu1, Henrik Marschall1, Karina E Hansen1

  • 1Department of Public Health, Aarhus University, Aarhus, Denmark.

BJOG : an International Journal of Obstetrics and Gynaecology
|January 13, 2025
PubMed
Summary

This study identified six key symptoms for endometriosis questionnaires: menstrual pain, pain during intercourse, cyclic defecation pain, cyclic pain, infertility, and frequent healthcare visits for pelvic pain. These findings aid in awareness and early detection of endometriosis.

Keywords:
Delphi studyearly detectionendometriosisinfertilitymenstrual painpelvic painsymptom assessment

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Area of Science:

  • Reproductive Medicine
  • Clinical Epidemiology
  • Patient-Reported Outcomes

Background:

  • Endometriosis diagnosis and characterization rely on symptom assessment.
  • Standardized questionnaires are crucial for consistent research and clinical evaluation.
  • A consensus on key symptoms is needed for effective endometriosis research tools.

Purpose of the Study:

  • To establish consensus on the most significant symptoms and consequences of endometriosis.
  • To inform the development of questionnaires for individuals with suspected or confirmed endometriosis.
  • To improve the characterization of endometriosis in the general population.

Main Methods:

  • A collaborative development of a 107-item symptom questionnaire by patients, doctors, and researchers.
  • A two-round modified e-Delphi study involving international participants (7 countries).
  • Consensus defined as 70% agreement on symptom relevance for inclusion.

Main Results:

  • Seventy-six participants completed Round 1, and 65 completed Round 2.
  • Six symptoms achieved consensus: menstrual pain, pain during sexual intercourse, cyclic pain during defecation, cyclic pain, infertility, and increased healthcare contacts for abdominal/pelvic pain.
  • These symptoms were identified through a rigorous, multi-stakeholder consensus process.

Conclusions:

  • Six core symptoms were identified for inclusion in endometriosis research questionnaires.
  • These symptoms are crucial for raising awareness and supporting early detection of endometriosis.
  • The consensus-based approach ensures relevance and applicability in diverse populations.