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Related Experiment Videos

Autism and lactic acidosis.

M Coleman, J P Blass

    Journal of Autism and Developmental Disorders
    |March 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study describes four patients with autism and lactic acidosis, suggesting a potential link between autism subgroups and metabolic disorders. Further research into carbohydrate metabolism may reveal new insights into autism causes.

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    Area of Science:

    • Biochemistry
    • Neurodevelopmental Disorders
    • Metabolic Syndromes

    Background:

    • Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with diverse etiologies.
    • Lactic acidosis is a biochemical abnormality indicating impaired cellular metabolism.

    Observation:

    • Four patients presented with coexisting autism and lactic acidosis.
    • One patient additionally exhibited hyperuricemia and hyperuricosuria.

    Findings:

    • The co-occurrence of autism and lactic acidosis in these patients suggests a potential shared underlying mechanism.
    • The presence of hyperuricemia and hyperuricosuria in one patient points towards specific metabolic pathway involvement.

    Implications:

    • These findings suggest that a subgroup of individuals with autism may have associated inborn errors of carbohydrate metabolism.

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  • This highlights the need for biochemical screening in certain autism populations.
  • Further investigation into metabolic pathways could offer novel therapeutic targets for autism.