A comprehensive pan-cancer analysis of RNF187 in human tumors
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View abstract on PubMed
Summary
This summary is machine-generated.RING Finger 187 (RNF187) is upregulated in 27 cancers and linked to patient prognosis. This study provides a comprehensive pan-cancer analysis of RNF187
Area Of Science
- Oncology
- Molecular Biology
- Genomics
Background
- RING Finger 187 (RNF187) is implicated in tumorigenesis.
- A comprehensive pan-cancer analysis of RNF187 is lacking.
Purpose Of The Study
- To investigate RNF187 expression across 33 human tumor types.
- To analyze RNF187's association with cancer prognosis and molecular features.
Main Methods
- Utilized TCGA and GTEx databases for pan-cancer analysis.
- Correlated RNF187 expression with clinical outcomes, RNA modifications, immune microenvironment, and genomic instability.
- Performed Gene Ontology (GO) and KEGG pathway analyses.
Main Results
- RNF187 was significantly upregulated in 27 cancer types.
- RNF187 expression correlated with patient prognosis, cancer-associated fibroblasts (CAFs), immune genes, TMB, MSI, and HRD.
- Pathway analysis suggested RNF187's involvement in autophagy, proteolysis, and ferroptosis.
Conclusions
- This inaugural pan-cancer study offers a comprehensive understanding of RNF187 in tumorigenesis.
- RNF187 is a potential pan-cancer oncogene with prognostic implications.
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