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Related Experiment Videos

Anterograde amnesia with oral lorazepam.

D S Mac, R Kumar, D W Goodwin

    The Journal of Clinical Psychiatry
    |April 1, 1985
    PubMed
    Summary
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    Lorazepam impairs memory recall. This study found that lorazepam significantly reduced delayed recall performance in healthy volunteers compared to a placebo, indicating amnestic effects.

    Area of Science:

    • Neuroscience
    • Psychopharmacology

    Background:

    • Benzodiazepines, including lorazepam, are commonly prescribed for anxiety and insomnia.
    • Potential cognitive side effects, particularly memory impairment, are a concern with benzodiazepine use.

    Purpose of the Study:

    • To investigate the amnestic effects of orally administered lorazepam in healthy individuals.
    • To assess lorazepam's impact on immediate and delayed verbal recall.

    Main Methods:

    • Double-blind, placebo-controlled study design.
    • Twelve healthy volunteers participated.
    • Word recall memory task assessing immediate and delayed recall.

    Main Results:

    • No significant difference in immediate recall between lorazepam and placebo groups.

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  • Significantly lower delayed recall scores in the lorazepam group (p < .01).

    • Conclusions:

    • Oral lorazepam administration results in significant impairment of delayed memory recall.
    • Lorazepam exhibits amnestic properties, affecting long-term memory consolidation.