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PDO screw threads versus fractional CO2 laser, after subcision, for atrophic acne scar remodelling: a randomized
Hamed Abdo1, Ahmed Shawky1, Mohammed Shaban Elkholy1
1Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Archives of Dermatological Research
|January 13, 2025
Summary
Fractional CO₂ laser combined with subcision offers superior long-term improvement for atrophic acne scars compared to polydioxanone (PDO) threads. While PDO threads provide quicker recovery, laser treatment yields higher patient satisfaction.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Regenerative Medicine
Background:
- Atrophic acne scars pose a significant treatment challenge.
- Subcision combined with fractional CO₂ lasers or polydioxanone (PDO) threads are used for scar remodeling.
- Comparative data on these adjunctive treatments is limited.
Purpose of the Study:
- To compare the clinical efficacy and patient satisfaction of subcision with fractional CO₂ laser versus subcision with PDO screw threads for atrophic acne scars.
Main Methods:
- A randomized controlled study involving 40 patients with atrophic acne scars.
- Group A: Subcision with PDO screw threads.
- Group B: Subcision followed by fractional CO₂ laser resurfacing. Outcome assessment included Goodman and Baron grading, Antera 3D imaging, and patient satisfaction.
Main Results:
- Both treatment groups showed significant scar improvement.
- Group B (subcision with fractional CO₂ laser) demonstrated greater reduction in scar severity and depth (p=0.022).
- Group A (subcision with PDO threads) had faster recovery and lower downtime, but Group B achieved higher patient satisfaction.
Conclusions:
- Subcision with fractional CO₂ laser provides superior long-term scar improvement for atrophic acne scars.
- Subcision with PDO threads offers a quicker recovery period.
- Treatment choice should consider patient preferences and specific scar characteristics.

