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Six-Month Outcomes in the Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children Study
Dongngan T Truong1,2, Felicia L Trachtenberg3, Chenwei Hu3
1Division of Cardiology, Department of Pediatrics, University of Utah and Primary Children's Hospital, Salt Lake City.
JAMA Pediatrics
|January 13, 2025
Summary
Most children with multisystem inflammatory syndrome in children (MIS-C) recover quickly after severe acute illness. Midterm outcomes are reassuring, with most cardiac dysfunction and coronary artery issues resolving by 6 months post-infection.
Area of Science:
- Pediatric Cardiology
- Infectious Diseases
- Critical Care Medicine
Background:
- Multisystem inflammatory syndrome in children (MIS-C) is a serious complication of COVID-19.
- Limited data exist on the midterm outcomes for children diagnosed with MIS-C.
Purpose of the Study:
- To assess the frequency and timeline of cardiac dysfunction, coronary artery aneurysms, and noncardiac issues up to 6 months after MIS-C.
- To characterize the recovery trajectory in pediatric patients following MIS-C.
Main Methods:
- A North American cohort study of 1204 children meeting CDC criteria for MIS-C.
- Echocardiography and patient-reported outcomes were used to track cardiac function and overall health at various follow-up intervals (2 weeks, 6 weeks, 6 months).
Main Results:
- While 42.3% of participants had reduced left ventricular ejection fraction (LVEF) during acute illness, most normalized by 6 months.
- Coronary artery abnormalities were present in some, but 92.3% normalized by 6 months.
- Patient-reported health status significantly improved, with 95.1% reporting return to baseline health by 6 months.
Conclusions:
- Children with MIS-C can experience severe acute illness but generally show rapid recovery.
- Midterm prognosis for MIS-C is reassuring, with most cardiac and noncardiac sequelae resolving within 6 months.
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