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Updated: Jun 2, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Beta-Blockers and Cutaneous Melanoma Outcomes: A Systematic Review and Random-Effects Meta-Analysis

Nicholas M Muller1,2, Samuel X Tan1,2, Nisal Vipulaguna1

  • 1Dermatology Research Centre, Frazer Institute, The University of Queensland, Brisbane, Australia.

Pigment Cell & Melanoma Research
|January 13, 2025
PubMed

Insights

Beta-blocker use may improve disease-free survival in cutaneous melanoma patients, but evidence is insufficient for treatment recommendations. Further research into pan-selective beta-blockers is suggested for potential benefits.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Cutaneous melanoma is a significant public health concern.
  • Beta-blockers are being explored as potential adjunctive therapies for melanoma due to their low cost and safety profile.
  • The current evidence regarding beta-blocker efficacy in melanoma treatment remains inconclusive.

Approach:

  • A systematic review and network meta-analysis was conducted.
  • The review included 12 studies encompassing 21,582 patients.
  • The analysis investigated the association between beta-blocker use and survival outcomes in cutaneous melanoma.

Key Points:

  • Beta-blocker use was associated with improved disease-free survival in cutaneous melanoma patients.
  • No significant associations were found for melanoma-specific survival or overall survival.
  • Preliminary evidence suggests pan-selective beta-blockers may offer a protective effect over cardio-selective agents.

Conclusions:

  • Current evidence is insufficient to support the routine use of beta-blockers for treating cutaneous melanoma.
  • Further research is warranted, particularly focusing on the specific effects of pan-selective beta-blockers.
  • Clarifying the role of specific beta-blocker types could inform future therapeutic strategies.
Keywords:
adjuvant therapybeta‐blockersdisease‐free survivaldrug repurposingmelanomameta‐analysispropranololskin cancer

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