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Rural Roads to cognitive Resilience (RRR): A prospective cohort study protocol.

Lilah M Besser1, Lisa Wiese2, Diane J Cook3

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This summary is machine-generated.

This study examines how air pollution and social factors impact cognitive decline in rural Florida communities. Findings will identify risks for social isolation and cognitive impairment in vulnerable populations.

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Area of Science:

  • Environmental Health
  • Neuroscience
  • Sociology

Background:

  • Ambient air pollution, adverse environments, social isolation (SI), low socioeconomic status (SES), and rural residence are linked to cognitive decline and Alzheimer's disease and related dementias (ADRD).
  • Research is needed on how air pollution and built/social environments influence SI and cognitive decline in rural, disadvantaged, ethnic minority communities.

Purpose of the Study:

  • To investigate the impact of fine particulate matter (PM2.5) from agricultural burning on SI and cognitive function.
  • To determine the effects of built and social environments on SI and cognitive function.
  • To contextualize SI and cognitive function across ethnoracial groups during burn and non-burn seasons.

Main Methods:

  • Recruit 1,087 community-dwelling, dementia-free adults (≥45 years) in rural Florida.
  • Conduct 36-month follow-ups with cognitive function and SI assessments every 6 months.
  • Utilize smartwatches, ecological momentary assessments (EMA), and PurpleAir monitors for PM2.5 data.

Main Results:

  • Analysis of PM2.5 exposure effects on SI and cognitive function.
  • Assessment of built and social environment influences on SI and cognitive function.
  • Comparison of SI and cognitive function across ethnoracial groups and seasons.

Conclusions:

  • Identify individual and community factors contributing to SI and cognitive decline risk.
  • Inform targeted interventions for vulnerable rural populations facing environmental and social challenges.