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Supervised Exercise for Patients With Metastatic Breast Cancer: A Cost-Utility Analysis Alongside the
Aniek E M Schouten1, Anouk E Hiensch1, Geert W J Frederix1
1Department of Epidemiology and Health Economics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Supervised exercise programs for metastatic breast cancer (mBC) patients improve quality of life and reduce healthcare costs. These interventions are likely cost-effective, especially in group settings, supporting their clinical implementation.
Area of Science:
- Oncology
- Health Economics
- Exercise Science
Background:
- Metastatic breast cancer (mBC) patients often experience reduced quality of life.
- Evidence on the cost-effectiveness of exercise interventions for mBC is limited.
- Supervised exercise programs require evaluation for clinical implementation.
Purpose of the Study:
- To assess the cost utility of a 9-month supervised exercise program for mBC patients.
- To compare the exercise group (EG) against a control group (CG) receiving usual care.
- To provide evidence for the economic viability of exercise in mBC care.
Main Methods:
- A cost-utility analysis was conducted alongside the PREFERABLE-EFFECT randomized controlled trial.
- 357 mBC patients were randomized into a supervised exercise group or a control group.
- Societal perspective analysis over 9 months, collecting data on healthcare resources, productivity, and quality of life.
Main Results:
- The exercise program yielded a small quality-adjusted life-year (QALY) gain.
- Total costs favored the exercise group, with savings of -€163 (scenario 1) and -€1,249 (scenario 2).
- Cost-effectiveness probability reached 65% (scenario 1) and 91% (scenario 2) at a €20,000/QALY threshold.
Conclusions:
- Supervised exercise improves quality of life and decreases costs for mBC patients.
- Group-based supervision is projected to yield greater cost savings.
- Findings support the reimbursement of supervised exercise for mBC patients.
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