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Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
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Regression tools for chemical release modeling: An additive manufacturing case study.

David E Meyer1, Raymond L Smith1, Elizabeth Lanphear2

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Estimating chemical releases using regression models is crucial for risk assessments. Various methods, including machine learning, accurately predicted volatile organic compound releases from 3D printing, informing exposure assessments.

Keywords:
Decision treeextrusionneural networkprocess read-acrossprocess releasessynthetic data

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Area of Science:

  • Environmental Science
  • Chemical Engineering
  • Data Science

Background:

  • Chemical release data are vital for industrial risk assessments but often unavailable.
  • Estimating these releases is necessary to understand potential exposures.

Purpose of the Study:

  • To explore the effectiveness of various regression methods for predicting chemical releases.
  • To inform chemical risk assessments using data from extrusion-based additive manufacturing.

Main Methods:

  • Assessed linear Least Squares, LASSO, Ridge regression, classification and regression tree, random forest, and neural network analysis.
  • Utilized secondary data on polymeric extrusion and evaluated synthetic data generation.
  • Tested model performance on a common dataset with varying features.

Main Results:

  • All assessed methods achieved predictions within 10% error for up to 98% of the test population.
  • Linear methods and neural networks performed well with fewer features; tree-based methods handled more features.
  • Including related process data improved predictions, while synthetic data showed minor gains.

Conclusions:

  • Regression modeling, including machine learning, shows promise for predicting chemical releases.
  • Model performance varies with feature selection, highlighting the need for careful feature engineering.
  • Future research should focus on primary data acquisition and model optimization for environmental release prediction.