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Venous Thromboembolism Occurrence and Association with Gastrointestinal Disorders in Children with Cystic Fibrosis:

Carolena Trocchia1, Dina Ashour2, Maua Mosha3

  • 1Department of Pediatric Gastroenterology, Lucille Packard Children's Hospital of Stanford, Palo Alto, California.

Seminars in Thrombosis and Hemostasis
|January 13, 2025
PubMed

Insights

Children with cystic fibrosis (CF) have a nearly 20-fold increased risk of venous thromboembolism (VTE). Specific gastrointestinal issues like pancreatitis and malnutrition are independent risk factors for VTE in these pediatric patients.

Area of Science:

  • Pediatric Medicine
  • Hematology
  • Gastroenterology

Background:

  • Venous thromboembolism (VTE) is a serious condition.
  • Cystic Fibrosis (CF) is a genetic disorder affecting multiple organs.
  • The relationship between CF, gastrointestinal (GI) manifestations, and VTE in children is not well understood.

Purpose of the Study:

  • To compare VTE prevalence in children with and without CF.
  • To identify GI conditions associated with VTE in pediatric CF patients.

Main Methods:

  • A multicenter case-control study using the TriNetX Research Network (2010-2020).
  • Inclusion of patients aged 0 to 21 years.
  • Analysis of International Classification of Diseases (ICD-9/10) codes.
  • Statistical analysis including Chi-square, Student's t-test, and multivariable logistic regression.

Main Results:

  • Nearly 20-fold increased VTE frequency in children with CF (130 vs. 7 per 10,000 patients).
  • Independent risk factors for VTE in CF patients included acute pancreatitis (aOR=3.80), biliary disease (aOR=2.17), gastrostomy status (aOR=2.01), and malabsorption/malnutrition (aOR=2.41).

Conclusions:

  • Children with CF exhibit a significantly higher incidence of VTE.
  • Specific GI manifestations are independent risk factors for VTE in pediatric CF population.
  • Findings highlight the need for VTE risk assessment in children with CF, particularly those with GI complications.

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