Fabrication and characterization of silver nanowire-coated porous alginate wet-laid webs for wound dressing applications

Ghazaleh Dini ¹, Gökçe Erdemir Cilasun ², Serap Erdem Kuruca ³

⁰Nano Science and Nano Engineering Department, Istanbul Technical University, Istanbul, Turkey.

International Journal of Biological Macromolecules +

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January 13, 2025

View abstract on PubMed

Summary

This study introduces cost-effective, antibacterial alginate fibrous dressings using wet spinning and wet-laying methods. These novel materials offer superior swelling, biocompatibility, and wound healing potential.

Area Of Science

Biomaterials Science
Materials Engineering
Textile Science

Background

Healthcare organizations face significant financial burdens from wound care.
There is a critical need for novel, cost-efficient wound dressings.
Alginate-based materials show promise for wound healing applications.

Purpose Of The Study

To develop novel antibacterial alginate-based fibrous materials for wound care.
To create cost-effective dressings with enhanced structural and functional properties.
To investigate the antibacterial and biocompatibility aspects of silver nanowire-coated alginate webs.

Main Methods

Fabrication of porous and non-porous Ca-alginate fibers via wet spinning.
Utilizing polyvinyl alcohol (PVA) as a pore-forming agent for porous fibers.
Construction of wet-laid webs from alginate fibers and subsequent coating with silver nanowires (AgNWs).

Main Results

Porous and non-porous alginate fibers with controlled diameters were successfully produced.
Wet-laid webs exhibited high swelling ability (12x for porous, 5x for non-porous).
Silver nanowire coating imparted significant antibacterial properties, with excellent cytocompatibility and cell proliferation support.

Conclusions

The developed wet-laid alginate-based fibrous dressings are multifunctional, offering low cytotoxicity and superior swelling capacity.
Silver nanowire-coated wet-laid webs represent a promising, cost-effective approach for advanced wound care materials.
These novel dressings demonstrate significant potential for supporting wound healing through antibacterial activity and biocompatibility.