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Updated: Jun 13, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Effect of the thinking healthy programme-based internet intervention model for maternal perinatal depression: A pilot
Jiamiao Dai1, Yingjuan Huang1, Jun Liu1
1Center for Women's and Children's Health, Wuhan University School of Nursing, Wuhan University, 115 Donghu Road, Wuhan 430071, Hubei, China.
The Thinking Healthy Programme (THP) effectively reduced perinatal depressive symptoms in Chinese women. This evidence-based intervention, delivered online by nurses, also showed benefits for maternal and infant health, proving feasible for non-specialist implementation.
Area of Science:
- Maternal and Child Health
- Psychosocial Interventions
- Mental Health Research
Background:
- The Thinking Healthy Programme (THP) is an established, evidence-based psychosocial intervention adaptable for delivery by non-specialists.
- While THP has been utilized globally in maternal health, its application within Chinese maternal and child health settings remained undocumented.
- This study addresses the gap by exploring THP's feasibility in China.
Purpose of the Study:
- To assess the feasibility of the Thinking Healthy Programme (THP) model for enhancing perinatal mental health and infant development.
- To evaluate the effectiveness of THP when implemented by non-psychologists, such as nurses, among Chinese pregnant women.
- To examine improvements in perinatal depressive symptoms and infant growth.
Main Methods:
- A randomized controlled trial involving 122 pregnant women with elevated depressive symptoms (Edinburgh Postnatal Depression Scale [EPDS] ≥ 10) in Fujian Province.
- Participants were assigned to either an intervention group (THP online delivery + enhanced usual care) or a control group (enhanced usual care only).
- Maternal depressive symptoms (EPDS, PHQ-9), infant growth, breastfeeding duration, and BMI-for-age z-scores were assessed at baseline, 3 months, and 6 months postpartum.
Main Results:
- The Generalized Linear Mixed Model revealed significant time effects on EPDS and PHQ-9 scores, indicating a reduction in depressive symptoms within the intervention group over time (p < 0.001).
- The intervention group demonstrated statistically significant longer breastfeeding duration (p = 0.012) at 6 months postpartum compared to the control group.
- While not statistically significant, the intervention group showed a trend towards lower BMI-for-age z-scores post-intervention.
Conclusions:
- The THP-based online intervention model is feasible and effective in improving maternal perinatal depressive symptoms and offers benefits for maternal and infant health.
- The findings support the adaptability and implementation of the THP model by non-psychologists in Chinese maternal and child health contexts.
- Limitations include a single-center design and small sample size; further large-scale, multicenter studies are recommended to confirm these findings and explore long-term effects.
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