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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

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Pretreatment plasma vitamin D and response to neoadjuvant chemotherapy in breast cancer: evidence from pooled

Chi Shu^1,2, Qian Yang³, Jun Huang^4,5

¹Department of General Surgery, Division of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, China.

International Journal of Surgery (London, England)

|January 14, 2025

Summary

This summary is machine-generated.

Vitamin D deficiency in breast cancer patients is linked to a poorer response to neoadjuvant chemotherapy (NAC). This meta-analysis suggests vitamin D levels may impact treatment outcomes, warranting further research into supplementation.

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Area of Science:

Oncology
Nutritional Science
Chemotherapy Research

Background:

Biological evidence suggests vitamin D has antitumor properties.
The predictive role of vitamin D levels for neoadjuvant chemotherapy (NAC) response in breast cancer (BC) remains unclear.

Purpose of the Study:

To investigate the association between pretreatment vitamin D levels and NAC response in breast cancer patients.
To evaluate the impact of vitamin D on subsequent survival outcomes.

Main Methods:

Systematic literature search of Medline, Embase, Cochrane Library, and Web of Science databases.
Meta-analysis of six retrospective cohort studies (1291 BC patients) using a random-effects model.
Primary outcome: pathological complete response (pCR); secondary outcomes: overall pathological response and event-free survival (EFS).

Main Results:

Vitamin D deficiency was significantly associated with a 50% increased odds of non-pCR after NAC (OR=1.50).
A significant association was found between vitamin D levels and overall pathological response (OR=1.33).
A trend towards poorer event-free survival was observed in vitamin D deficient patients, though not statistically significant.

Conclusions:

Pretreatment vitamin D deficiency is linked to inferior NAC response in breast cancer patients.
Further large-scale prospective studies are needed to confirm these findings.
The potential role of vitamin D supplementation to improve NAC response and prognosis requires investigation.