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Modeling virus filtration: Materials, applications, and mechanism
Hironobu Shirataki1, Linda Gudex2, Sumith Ranil Wickramasinghe3,4
1Bioprocess Division, Asahi Kasei Medical, Tokyo 100-0006, Japan.
Iscience
|January 14, 2025
Summary
Virus filtration (VF) is a key method for product purification and virus removal, offering high recovery rates. This review details VF membrane technology, mechanisms, and predictive models for filtration behavior and virus reduction.
Area of Science:
- Biotechnology
- Chemical Engineering
- Membrane Science
Background:
- Ensuring virus safety in finished products is critical.
- Virus filtration (VF) is a preferred method for virus removal and purification.
- VF offers high recovery (>90%) and preserves molecule characteristics.
Purpose of the Study:
- To review materials and applications of virus filtration (VF) membranes.
- To highlight the unique characteristics and development of VF membranes.
- To examine virus removal mechanisms and filtration models for VF.
Main Methods:
- Review of existing literature on VF membrane technology.
- Analysis of VF membrane materials, applications, and development.
- Examination of virus removal mechanisms and filtration modeling principles.
Main Results:
- VF membranes are effective for virus removal and product purification.
- Modeling of VF is based on microfiltration (MF) and ultrafiltration (UF) principles with modifications.
- VF allows for separation of product molecules from virus particles with high recovery.
Conclusions:
- VF is a highly effective and versatile technology for virus safety.
- Understanding VF mechanisms and modeling is crucial for predicting filtration performance.
- Continued development of VF membranes enhances purification capabilities.
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