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Updated: Jun 2, 2025
03:47
Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
173
Correlation between Autoimmune Hashimoto's Thyroiditis and Helicobacter pylori Infection: A Case-Control Study
Mahla Shajari1, Maryam Rezaei2, Fereshteh Osmani3
1Student Research Committee, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Middle East Journal of Digestive Diseases
|January 14, 2025
Summary
Helicobacter pylori infection may influence autoimmune thyroid disease. While not directly linked to Hashimoto's thyroiditis prevalence, H. pylori antigen levels correlated positively with thyroid peroxidase antibody (TPO-Ab) levels in patients.
Area of Science:
- Endocrinology
- Immunology
- Gastroenterology
Background:
- Infectious agents, such as Helicobacter pylori, are recognized environmental factors that can trigger autoimmune diseases.
- Autoimmune thyroid diseases (AITDs) are a group of disorders where the immune system attacks the thyroid gland.
Purpose of the Study:
- To investigate the potential correlation between autoimmune Hashimoto's thyroiditis and H. pylori infection.
- To determine if H. pylori infection is associated with specific markers of autoimmune thyroid disease.
Main Methods:
- A case-control study involving 74 participants (38 Hashimoto's thyroiditis patients, 36 healthy controls).
- Data collection included demographic information, thyroid function tests (TSH, FT4), and anti-thyroid peroxidase antibody (TPO-Ab) levels.
- H. pylori antigen detection was performed on stool samples using ELISA kits.
Main Results:
- No statistically significant difference in H. pylori infection rates was observed between Hashimoto's thyroiditis patients (58.6%) and the control group (41.4%).
- A significant positive correlation was found between thyroid peroxidase antibody (TPO-Ab) levels and H. pylori infection (r=0.2, P=0.03).
Conclusions:
- H. pylori infection, identified by antigen detection, showed an association with elevated TPO-Ab levels.
- This suggests a potential link between H. pylori and the immune response in autoimmune thyroid conditions, specifically Hashimoto's thyroiditis.
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