Related Experiment Video

Updated: Jun 2, 2025

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
10:12

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Published on: August 8, 2013

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Elevated Troponin T (TnT) in Non-acute Coronary Syndrome (ACS) Due to Dermatomyositis

Abdulaziz S Alnakhli1, Kawther AlShaikh1, Ahad Al Saud1

  • 1Emergency Medicine, King Khalid University Hospital, Riyadh, SAU.

Cureus
|January 14, 2025
PubMed

Troponin is a highly specific biomarker for myocardial injury. It plays a critical role in the diagnosis of acute coronary syndrome (ACS). However, elevated troponin levels are not exclusively due to cardiac ischemia and may be observed in many non-cardiac conditions, including inflammatory myopathies. These scenarios present significant diagnostic challenges, particularly when clinical symptoms and ECG (electrocardiogram) findings do not align with cardiac pathology. Recognizing alternative etiologies, such as autoimmune diseases, is essential to prevent unnecessary investigations and ensure appropriate management. This report emphasizes the importance of a comprehensive diagnostic approach to identify non-cardiac causes of high troponin levels and to avoid misdiagnosing patients.

Keywords:
acute coronary syndromedermatomyositishigh troponin-tinflammatory myopathiespolymyositis

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