A Review on the Role of Human Solute Carriers Transporters in Cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Solute carrier (SLC) transporters are overexpressed in many cancers, driving tumor growth and proliferation. Targeting these amino acid transporters offers a promising strategy for cancer therapy and drug resistance.
Area Of Science
- Oncology
- Molecular Biology
- Biochemistry
Background
- Cancer cells exhibit increased amino acid requirements due to rapid proliferation.
- Solute carrier (SLC) transporters facilitate amino acid uptake, and their dysregulation is implicated in cancer development.
- Overexpression of SLC transporters may arise from complex interactions with other biomolecules in the tumor microenvironment.
Purpose Of The Study
- To review the role of solute carrier (SLC) transporters in cancer progression.
- To investigate the association between SLC transporter expression and tumor growth.
- To identify SLC transporters as potential therapeutic targets in oncology.
Main Methods
- Comprehensive literature search of major scientific databases including Google Scholar, Web of Science, PubMed, Cochrane Library, and EMBASE.
- Inclusion of English-language articles published up to August 2024 focusing on human SLCs and cancer.
- Systematic review and synthesis of existing research findings.
Main Results
- SLC transporter overexpression is linked to tumor cell proliferation and angiogenesis in various cancers (thyroid, pancreatic, lung, hepatocellular, colon).
- SLCs activate key signaling pathways like mTOR and PI3K/AKT, promoting cell growth, protein synthesis, and inhibiting apoptosis.
- SLC transporters influence drug resistance, tumor microenvironment, and immune response, highlighting their multifaceted role.
Conclusions
- SLC transporters play a critical role in the progression of diverse cancer types.
- Further case-control studies are warranted to definitively establish the role of amino acid transporters in cancer development.
- Targeting SLC transporters presents a viable therapeutic strategy in cancer treatment.
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