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Updated: Jul 26, 2026
From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Conversion of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma to Angioimmunoblastic T-cell Lymphoma: a Rare
Background:
Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma (PTCL) and accounts for 2% of all non-Hodgkin lymphomas. Its typical characteristics include an aggressive course, progressive lymphadenopathy, hepatosplenomegaly, systemic symptoms, anemia, hypergammaglobulinemia, and generally poor prognosis.
Methods:
We describe a rare case in which the left inguinal lymph node was completely excised and biopsied one year ago. Based on histomorphology and immunohistochemistry, B-cell small lymphocytic lymphoma (CLL/SLL) was diagnosed. Routine bone marrow examination indicated the presence of immature lymphocytes; however, immunophenotyping showed no significant abnormal lymphocytes. One month ago, the patient developed swelling in the left lower limb, which gradually worsened. A fine-needle aspiration biopsy of the left inguinal lymph node revealed angioimmunoblastic T-cell lymphoma.
Results:
The final diagnosis for this patient is a transformation from B-cell small lymphocytic lymphoma to angioimmunoblastic T-cell lymphoma (AITL) one year after the initial diagnosis.
Conclusions:
In this report, we present a rare case of AITL. The aim is to enhance awareness among readers regarding the clinical, immunological, and phenotypic characteristics of various forms of AITL.
