A Rare Hemoglobin Variant: Hemoglobin G-Siriraj, in a Moroccan Patient

Area of Science:

• Hematology
• Clinical Chemistry

Background:

• Hemoglobin G-Siriraj is a rare hemoglobin variant resulting from a specific β-globin gene mutation (HBB: c.22G>A).
• This paper focuses on the chromatographic and electrophoretic characteristics of Hemoglobin G-Siriraj for presumptive identification.
• This marks the first documented instance of Hemoglobin G-Siriraj in Morocco.

Observation:

• The variant was detected in a 44-year-old Moroccan patient during HbA1c measurement using high-performance liquid chromatography.
• Discrepancies observed between capillary electrophoresis and acid agarose electrophoresis suggested heterozygous Hemoglobin G-Siriraj.

Findings:

• High-performance liquid chromatography and electrophoresis revealed characteristics consistent with Hemoglobin G-Siriraj.
• Definitive identification of this rare hemoglobin variant requires globin gene analysis.

Implications:

• Rare hemoglobin variants pose significant diagnostic challenges in clinical laboratories.
• Integrating clinical data with cytological and biochemical findings is crucial for accurate diagnosis of hemoglobinopathies.