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Published on: October 17, 2018
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Association between systemic inflammatory response index and cerebral small vessel disease
Ting Zhuang1, Xiao Xu1, Peiyu Huang2
1The Affiliated LiHuiLi Hospital of Ningbo University, Ningbo 315040, China.
Summary
Elevated Systemic Inflammatory Response Index (SIRI) is linked to increased Cerebral Small Vessel Disease (CSVD) risk and severity. Higher SIRI correlates with key CSVD imaging markers like White Matter Hyperintensity and lacunes.
Area of Science:
- Neurology
- Inflammation Research
- Medical Imaging
Background:
- Cerebral Small Vessel Disease (CSVD) is a significant cause of stroke and cognitive decline.
- The role of systemic inflammation in CSVD pathogenesis requires further elucidation.
- Systemic Inflammatory Response Index (SIRI) is a novel marker reflecting inflammatory status.
Purpose of the Study:
- To investigate the association between SIRI and the presence of CSVD.
- To explore the relationship between SIRI and specific CSVD imaging markers.
- To determine if SIRI can predict CSVD risk and progression.
Main Methods:
- A cohort of 344 neurology patients (223 with CSVD, 121 without) was analyzed.
- Baseline characteristics and SIRI values were compared between groups.
- Multivariate logistic regression assessed the association of SIRI with CSVD and its imaging markers (WMH, lacunes, PVS, RSSI).
Main Results:
- Patients with CSVD had significantly higher SIRI values compared to controls.
- Elevated SIRI was independently associated with an increased risk of CSVD.
- Higher SIRI levels correlated with moderate-to-severe White Matter Hyperintensity (WMH), lacunes, and Recent Small Subcortical Infarcts (RSSI).
Conclusions:
- Elevated SIRI is an independent predictor of CSVD occurrence.
- SIRI is associated with the severity of key CSVD imaging markers, including WMH, lacunes, and RSSI.
- SIRI may serve as a valuable inflammatory biomarker for assessing CSVD risk and disease progression.
Keywords:
Cerebral small vessel diseaseImaging markersRecent small subcortical infarctSystemic inflammatory response indexWhite matter hyperintensity, lacunesMore Related Videos
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