Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Formation by Endochondral Ossification

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting of Wnt-β-Catenin Pathway in Recurrent Ameloblastoma.

The New England journal of medicine·2026

Same author

A Multicenter Retrospective Outcomes Analysis of Patients with Localized Synovial Sarcoma.

Cancer research communications·2026

Same author

IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors.

The Journal of clinical investigation·2026

Same author

A phase 1b/2 study of cabozantinib in combination with pembrolizumab in advanced cutaneous melanoma.

Cancer·2026

Same author

Cabozantinib and temozolomide in patients with unresectable or metastatic leiomyosarcoma and other soft tissue sarcomas: a multicentre, single-arm, lead-in phase 2 trial.

The Lancet. Oncology·2026

Same author

Complete response of somatic <i>POLE</i>-ultramutated recurrent undifferentiated uterine sarcoma to pembrolizumab and concurrent radiotherapy.

Gynecologic oncology reports·2025

Search research articles

Related Experiment Video

Updated: Jul 8, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Human chorionic gonadotropin-secreting osteosarcoma.

Natalia Gabriela Sanchez¹, Andrew E Horvai¹, Emanuela Zacco²

¹Pathology, University of California San Francisco, San Francisco, California, USA.

BMJ Case Reports

|January 14, 2025

Summary

This summary is machine-generated.

A rare paraneoplastic syndrome, beta human chorionic gonadotropin (β-hCG) secretion, was identified in a patient with osteosarcoma. The tumor cells produced β-hCG, suggesting its potential use as a marker for monitoring disease.

Area of Science:

Oncology
Endocrinology
Pathology

Background:

Paraneoplastic syndromes are rare manifestations of cancer, impacting various bodily systems.

Keywords:

Cancer - see Oncology Genetics Oncology Pathology Surgical oncology

More Related Videos

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

Related Experiment Videos

Last Updated: Jul 8, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Author Spotlight: Replicating Human Osteosarcoma Progression in Immunodeficient Mice for Cancer Study

Published on: March 22, 2024

Beta human chorionic gonadotropin (β-hCG) secretion is an uncommon paraneoplastic syndrome.

Osteosarcoma is a primary bone malignancy typically affecting younger individuals.