Organoids, organs-on-chips, complex in vitro model: Definitions, applications, validation, ethics.

Area of Science:

• Biomedical Engineering
• Pharmacology
• In Vitro Models

Background:

• Emergence of advanced in vitro biological models (organoids, organs-on-chips) over the past decade.
• These models replicate human physiology and pathologies, revolutionizing research and development.
• Involvement of diverse stakeholders including academia, pharmaceutical companies, and regulatory agencies.

Purpose of the Study:

• Examine issues and challenges associated with new biomimetic technologies.
• Formulate recommendations to strengthen the national academic and industrial sectors.
• Accelerate the development and validation of novel in vitro models.

Main Methods:

• Roundtable discussion at the Ateliers de Giens (Giens Workshops).
• Expert examination of technological advancements and their implications.
• Consensus-building on strategic recommendations.

Main Results:

• Identification of key challenges and opportunities in biomimetic model development.
• Acknowledgement of improved predictability and ethical benefits (reduced animal testing).
• Emphasis on the need for enhanced national sector structuring.

Conclusions:

• Biomimetic models are crucial for future medicine and pharmacology.
• Strengthening national collaboration is essential for accelerating model development and validation.
• These technologies offer a path towards more predictive and ethical biomedical research.