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Adiponectin removal by the human kidney: A preliminary study
Daniela Picciotto1, Manrico Balbi2, Gianmarco Rosa3
1Clinica Nefrologica Dialisi e Trapianto, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|January 14, 2025
Summary
The liver and kidneys remove adiponectin (APN), an insulin-sensitizing hormone, from the blood. Reduced kidney function in renal disease may elevate circulating APN levels.
Area of Science:
- Endocrinology
- Metabolic Research
- Renal Physiology
Background:
- Adiponectin (APN) is an adipocyte-derived hormone with significant insulin-sensitizing and anti-inflammatory effects.
- Adipose tissue is the primary source of circulating APN, but its clearance pathways in humans remain unclear.
Purpose of the Study:
- To identify the primary sites of adiponectin (APN) removal from the bloodstream in humans.
- To investigate the role of the kidney in APN metabolism.
Main Methods:
- Analysis of arterio-venous concentration differences for APN in hepatic and renal circulation.
- Review of existing data on inter-organ exchange of amino acids and cytokines.
Main Results:
- Both the liver and kidneys demonstrated a significant reduction in total APN concentrations compared to arterial levels, indicating removal.
- A similar, though not statistically significant, trend was observed for high molecular weight (HMW) APN removal in both organs.
Conclusions:
- The splanchnic organs and kidneys are identified as major sites for APN clearance in humans.
- Impaired kidney function in renal disease may contribute to elevated circulating APN levels due to reduced renal handling.
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