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Related Experiment Video

Updated: Jun 23, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

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Published on: March 27, 2018

Syndecan-1 in the Serum of Deceased Kidney Donors as a Potential Biomarker of Kidney Function.

Pavel Navratil¹, Sukhdeep Sahi², Petra Hruba³

¹Department of Urology, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic; Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.

Transplantation Proceedings

|January 14, 2025

Summary

Serum syndecan-1 may indicate donor kidney quality, correlating with donor creatinine levels. However, this study found no link between syndecan-1 and short-term kidney transplant recipient outcomes.

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Published on: March 4, 2022

Area of Science:

Nephrology
Transplantation immunology
Biomarker discovery

Background:

Kidney transplantation is optimal for end-stage renal disease but faces challenges in predicting outcomes.
Donor organ quality is a critical factor influencing graft survival.
Accurate biomarkers are needed to assess organ quality.

Purpose of the Study:

To evaluate serum syndecan-1 as a biomarker for donor kidney quality.
To correlate serum syndecan-1 levels with donor characteristics.
To investigate the association between serum syndecan-1 and short-term kidney transplant outcomes.

Main Methods:

Retrospective observational cohort study of 80 deceased donors and 104 kidney recipients.
Measured serum syndecan-1 levels in donors.
Correlated syndecan-1 with donor characteristics and short-term outcomes (delayed graft function, serum creatinine at 3 months).

Main Results:

Higher serum syndecan-1 correlated with donor's pre-procurement creatinine levels (R = 0.32, p = 0.01).
Syndecan-1 levels were marginally higher in donors with acute kidney injury (p = 0.07).
No association was found between donor syndecan-1 levels and recipient short-term outcomes.

Conclusions:

Serum syndecan-1 shows potential as a biomarker for assessing donor kidney quality.
Further research is needed to validate these findings and explore implications for transplant success.
The role of syndecan-1 in recipient outcomes requires additional investigation.