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Diabetes in China: epidemiology, pathophysiology and multi-omics
Weiping Jia1,2, Juliana Cn Chan3, Tien Y Wong4,5
1Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. wpjia@sjtu.edu.cn.
Nature Metabolism
|January 14, 2025
Summary
China faces a significant diabetes epidemic, driven by lifestyle changes. Understanding epidemiological trends, risk factors, and genetic insights is crucial for personalized prevention and treatment strategies.
Area of Science:
- Endocrinology and Public Health
Background:
- Diabetes is a global epidemic, with China having the highest number of affected individuals.
- Rapid ecological and lifestyle shifts in China have significantly impacted diabetes epidemiology and risk factors.
Purpose of the Study:
- To summarize epidemiological trends of diabetes in China.
- To explore the impact of traditional and emerging risk factors on diabetes prevalence.
- To review genetic, metagenomic, and metabolomic studies for insights into pathogenesis and management.
Main Methods:
- Review of epidemiological data on diabetes in China.
- Analysis of traditional and emerging risk factors.
- Synthesis of findings from genetic, metagenomic, and metabolomic research.
Main Results:
- Significant alterations in diabetes epidemiology and risk factors due to lifestyle changes.
- Genetic, metagenomic, and metabolomic studies offer insights into diabetes pathogenesis.
- Heterogeneity in data presents challenges but enables personalized diagnosis and treatment.
Conclusions:
- National strategies and research are vital for improving diabetes detection, prevention, and control in China.
- Personalized care approaches are essential to mitigate societal impacts and maintain quality of life.
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