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Potential Correlation Between Hematological Parameters and Palpitation in Outpatients With COVID-19: A Retrospective

Lei Zhang1, Ting Chen2, Ling Wei2

  • 1Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Journal of Clinical Laboratory Analysis
|January 15, 2025
PubMed

Insights

Mild COVID-19 patients with palpitations showed increased coagulation issues, not myocardial damage. Focus on coagulation tests, not cardiac markers, to manage circulation and prevent thrombosis in mild cases.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Hematology

Background:

  • Limited research exists on COVID-19's cardiac effects, especially in mild infections.
  • Previous studies primarily used imaging or pathology, with few analyzing myocardial markers in mild cases.

Purpose of the Study:

  • To investigate changes in blood indices, including myocardial markers and coagulation parameters, in patients experiencing palpitations during a mild COVID-19 outbreak.
  • To compare these changes against pre-outbreak periods to identify COVID-19-related effects.

Main Methods:

  • Retrospective analysis of outpatient blood samples from Beijing Anzhen Hospital during the 2022 COVID-19 outbreak.
  • Comparison with control periods in 2020 and 2021.
  • Focus on routine blood tests, coagulation indices, myocardial markers, and blood cell counts in patients with palpitations.

Main Results:

  • A significant increase (4.87-fold) in patients with palpitations was observed during the 2022 outbreak.
  • Myocardial damage markers showed no significant increase; some even decreased within normal ranges.
  • Elevated D-dimer, fibrinogen/fibrin degradation product (FDP) levels, neutrophils, monocytes, and platelets were noted in patients with palpitations.

Conclusions:

  • For mild COVID-19 cases presenting with palpitations, clinical focus should shift from myocardial markers to coagulation test results.
  • Monitoring coagulation indices is crucial for improving circulation and preventing thrombosis in these patients.
Abstract

Keywords:
COVID‐19coagulationmyocardial markersoutpatientspalpitation

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