Transition metal-catalyzed cross-coupling reactions of N-aryl-2-aminopyridines
Fatemeh Doraghi1, Lina Rezainia2, Mohammad Hossein Morshedsolouk1,2
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences Tehran Iran momahdavi@tums.ac.ir.
Abstract:
Due to the presence of the pyridyl directing group, N-aryl-2-aminopyridines can quickly form stable complexes with metals, leading to cyclization and functionalization reactions. A large number of N-heterocycles and nitrogen-based molecules can be easily constructed via this direct and atom-economical cross-coupling strategy. In this review, we have highlighted the transformations of N-aryl-2-aminopyridines in the presence of various transition metal catalysts, such as palladium, rhodium, iridium, ruthenium, cobalt and copper.
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