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Association Between Endocrine-Disrupting Chemicals Exposure and Attention-Deficit/Hyperactivity Disorder Symptoms in
Kang-Eun Yeo1,2, Seungbee Lim3, Aelin Kim3
1Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Journal of the Korean Academy of Child and Adolescent Psychiatry
|January 15, 2025
Summary
Exposure to phthalates, but not bisphenols, is linked to increased impulsivity in children with attention-deficit/hyperactivity disorder (ADHD). This study measured urinary endocrine-disrupting chemicals (EDCs) and ADHD symptom severity in children.
Area of Science:
- Environmental Health
- Neuroscience
- Pediatrics
Background:
- Endocrine-disrupting chemicals (EDCs) are environmental contaminants linked to various health issues.
- Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children.
- Previous research suggests potential links between EDC exposure and ADHD, but findings are inconsistent.
Purpose of the Study:
- To investigate the association between exposure to specific EDCs (phthalates, bisphenols) and ADHD symptom severity in children.
- To utilize objective neuropsychological tests to assess ADHD symptoms in relation to EDC exposure.
- To examine the relationship between urinary EDC concentrations and ADHD symptom severity in medication-naïve children.
Main Methods:
- Included 67 medication-naïve children aged 6-16 years diagnosed with ADHD.
- Measured urinary concentrations of phthalates, bisphenol A, bisphenol F, and bisphenol S.
- Assessed ADHD symptom severity using neuropsychological tests and clinical scales, analyzed with statistical models.
Main Results:
- A significant correlation was found between urinary phthalate metabolite levels and commission errors on the visual Advanced Test of Attention.
- No significant associations were observed between bisphenol (A, F, S) levels and ADHD symptom indicators.
- Phthalate exposure was linked to impulsivity, supporting prior survey-based findings.
Conclusions:
- Phthalate exposure may influence impulsivity in children with ADHD.
- Current evidence does not strongly associate bisphenol exposure with ADHD symptoms in this cohort.
- Further research is warranted to elucidate the complex interplay between EDCs and neurodevelopmental disorders.
Keywords:
Attention-deficit/hyperactivity disorderBisphenol ABisphenol FBisphenol SEndocrine disrupting chemicalsNeuropsychological testPhthalateMore Related Videos
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