Association of age at menopause with type 2 diabetes mellitus in postmenopausal women: a systematic review and meta-analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Earlier menopause is linked to a lower risk of developing type 2 diabetes mellitus (T2DM). This meta-analysis highlights the complex relationship between menopausal age and T2DM risk, crucial for prevention strategies.
Area Of Science
- Endocrinology
- Metabolic Health
- Epidemiology
Background
- Menopause, typically occurring between 48-52 years, involves decreased estrogen levels, contributing to metabolic changes.
- Visceral obesity and reduced estrogen during menopause are associated with insulin resistance and increased type 2 diabetes mellitus (T2DM) risk.
- Rising T2DM incidence necessitates identifying predisposing factors like menopausal age for improved prevention and management.
Purpose Of The Study
- To investigate the association between menopausal age and the risk of developing type 2 diabetes mellitus (T2DM).
- To synthesize evidence from existing studies through a meta-analysis to quantify this relationship.
Main Methods
- A systematic literature search was conducted across PubMed, Scopus, and Google Scholar up to August 4, 2023.
- Studies meeting inclusion criteria were reviewed, extracting sample size and T2DM cases in post-menopausal women.
- Effect sizes and confidence intervals were calculated and combined across 17 studies.
Main Results
- A significant association was found between menopausal age and T2DM risk.
- Women with menopause onset > 45 years showed a significantly decreased T2DM risk (OR = 0.13; 95% CI: 0.04, 0.22).
- For menopause onset > 50 and > 55 years, the odds ratios were 0.44 (95% CI: -1.12, 2.00) and 0.21 (95% CI: -1.39, 1.82), respectively.
Conclusions
- Earlier menopausal age is associated with a reduced risk of developing T2DM.
- The findings underscore the intricate link between the timing of menopause and T2DM development.
- Understanding this relationship is vital for targeted T2DM prevention and management strategies.
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