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Updated: Jun 2, 2025

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

Obstetric penicillin allergy evaluations.

Lakshmi G Nair¹, S Shahzad Mustafa^2,3, Allison Ramsey^2,3

¹Division of Allergy and Clinical Immunology, National Jewish Health, Denver.

The Journal of Allergy and Clinical Immunology. Global

|January 15, 2025

Summary

This summary is machine-generated.

Most pregnant individuals reporting penicillin allergy can safely tolerate penicillin after evaluation. A direct referral phone line improved evaluation show rates, successfully delabeling most patients.

Keywords:

Penicillin allergy drug allergy

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Area of Science:

Obstetrics and Gynecology
Allergy and Immunology
Clinical Research

Background:

Penicillin allergy is frequently reported but often inaccurate, affecting 5-15% of the global population, including 3-10% of pregnant women.
Over 90% of patients with a reported penicillin allergy can tolerate the medication after appropriate evaluation.
A history of penicillin allergy can lead to suboptimal treatment choices and adverse health outcomes during pregnancy.

Purpose of the Study:

To assess the feasibility and safety of a direct referral phone line system for obstetric penicillin allergy evaluations.
To evaluate obstetric outcomes in pregnant patients undergoing penicillin allergy testing.
To determine the effectiveness of a streamlined referral process in increasing patient participation in allergy evaluations.

Main Methods:

Prospective evaluation of pregnant patients referred via a direct phone line from obstetric practices.
Utilized penicillin skin testing (PST) followed by amoxicillin challenge for negative PST results.
Direct oral challenge was performed in select low-risk cases; data analyzed using descriptive statistics.

Main Results:

A total of 251 out of 324 referred patients (77.5%) attended in-office evaluations.
Of those evaluated, 95.2% underwent PST with subsequent oral challenge, and 97.2% of PSTs were negative.
229 out of 230 patients with negative PST tolerated amoxicillin challenge, indicating successful delabeling for most.

Conclusions:

This study represents the largest to date demonstrating the safety and feasibility of a phone line referral system for obstetric penicillin allergy evaluations.
The implemented system achieved higher show rates compared to previous studies.
The majority of patients evaluated through this system were successfully delabeled, improving their potential treatment options.