Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC
- Vincenzo B Polsinelli 1, Karen Hanley-Yanez 2, Charles F McTiernan 2, Kalgi Modi 3, Jennifer Haythe 4, Hal Skopicki 5, Uri Elkayam 6, Leslie T Cooper 7, James D Fett 2,8, Dennis M McNamara 2,
- 1University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
- 2University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
- 3Louisiana State University Health Science Center, Shreveport, LA, United States of America.
- 4Columbia University, New York, NY, United States of America.
- 5Stony Brook Medical Center, Stony Brook, NY, United States of America.
- 6University of Southern California Los Angeles, CA, United States of America.
- 7Mayo Clinic Foundation, Jacksonville, FL, United States of America.
- 8Albert Schweitzer Hospital, Deschapelles, Haiti.
- 0University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.
|
January 15, 2025
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Elevated cathepsin-D (CD) levels in women with peripartum cardiomyopathy (PPCM) correlate with increased disease severity and poorer clinical outcomes. This suggests CD may play a role in PPCM pathogenesis and prognosis.
Area Of Science
- Cardiology
- Biochemistry
- Obstetrics
Background
- Cathepsin-D (CD) is a protease implicated in peripartum cardiomyopathy (PPCM) pathogenesis.
- CD cleaves prolactin (PRL) into a pro-apoptotic fragment during oxidative stress.
Purpose Of The Study
- To evaluate the relationship between cathepsin-D (CD) levels and disease severity in women with peripartum cardiomyopathy (PPCM).
- To assess the association of CD with clinical outcomes and myocardial recovery in PPCM patients.
Main Methods
- Prospective cohort study of 99 women with newly diagnosed PPCM.
- Serum CD levels measured by ELISA at study entry.
- Left ventricular ejection fraction (LVEF) assessed serially; survival free from major adverse cardiovascular events tracked up to 12 months post-partum.
Main Results
- PPCM patients exhibited higher CD levels compared to healthy controls (p < 0.001).
- Higher CD levels correlated with increased NYHA functional class (p = 0.001).
- Elevated CD levels were associated with reduced event-free survival (p = 0.008).
Conclusions
- Higher CD levels at diagnosis are linked to worse PPCM symptoms and impaired LVEF recovery.
- Circulating CD may be a biomarker for PPCM severity and influence myocardial recovery and clinical outcomes.
Related Experiment Videos
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.