Adenoid basal cell carcinoma: An underrecognized cervical malignancy

Area of Science:

• Gynecologic Oncology
• Pathology
• Cervical Cancer Research

Background:

• Adenoid basal cell carcinoma (ABCC) is a rare cervical malignancy.
• It exhibits an indolent nature but histologically resembles aggressive cancers.
• Accurate diagnosis is crucial to differentiate ABCC from more common, aggressive malignancies.

Observation:

• Three cases of cervical adenoid basal cell carcinoma (ABCC) are presented.
• All patients had a history of cervical dysplasia associated with high-risk human papillomavirus (HPV).
• Treatment modalities included hysterectomy for two patients and surveillance post-cold knife conization for one patient.

Findings:

• All three patients remain disease-free following their respective treatments.
• Immunohistochemistry (IHC) aids in distinguishing ABCC from other cervical pathologies.
• Accurate diagnosis is paramount for determining appropriate management strategies.

Implications:

• Optimal treatment for ABCC typically involves surgical management, such as hysterectomy with lymph node assessment.
• For patients desiring future fertility, excisional biopsy with comprehensive pathologic evaluation for invasive carcinoma is a viable option.
• Distinguishing ABCC is critical for effective patient management and achieving favorable prognoses.