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Rhizopogon luteolus and Ganoderma adspersum Extracts Inhibit Invasion through the Crosstalk between Anti-oxidant

Aydın Demiray1, Ege Rıza Karagür1, Gülsen Tel-Cayan2

  • 1Department of Medical Genetic, School of Medicine, Pamukkale University, Denizli, Turkey.

Anti-Cancer Agents in Medicinal Chemistry
|January 15, 2025
PubMed
Abstract

Insights

Mushroom extracts from Rhizopogon luteolus and Ganoderma adspersum show promise in fighting non-small cell lung cancer. These natural compounds inhibit cancer cell proliferation and invasion while promoting apoptosis, offering a potential new avenue for lung cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Mycology

Background:

  • Lung cancer is a leading cause of cancer mortality worldwide.
  • Protein kinase B (AKT) signaling pathways are implicated in non-small cell lung cancer (NSCLC) progression.
  • Mushrooms possess known antioxidant and anticancer properties, prompting investigation into their therapeutic potential.

Purpose of the Study:

  • To investigate the antioxidant, anti-invasion, and apoptosis-inducing effects of mushroom extracts in NSCLC.
  • To explore the underlying molecular mechanisms, including the AKT-Rb pathway.

Main Methods:

  • Utilized NSCLC cell lines (H1299, PC-3, PC-14).
  • Prepared and applied extracts of *Rhizopogon luteolus* and *Ganoderma adspersum* at calculated IC50 doses.
  • Assessed antiproliferative, anti-invasive, antioxidant, and apoptosis-inducing effects.
  • Employed Western blotting to analyze relevant signaling pathways.

Main Results:

  • Both *R. luteolus* and *G. adspersum* extracts demonstrated significant anti-proliferative and anti-invasive effects on NSCLC cells.
  • The mushroom extracts successfully induced apoptosis in cancer cells.
  • Enhanced antioxidant activity was observed, linked to the AKT-Rb pathway.

Conclusions:

  • *Rhizopogon luteolus* and *Ganoderma adspersum* extracts exhibit potent anticancer properties against NSCLC.
  • These extracts suppress lung cancer cell growth and invasion by modulating the p-Akt and Rb pathways.
  • Mushroom-derived compounds represent a promising therapeutic strategy for lung cancer treatment.
Keywords:
anti-apoptoticantioxidantganoderma adspersumnon-small cell lung cancer.pAKT/Rbrhizopogon luteolus

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