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Updated: Jun 2, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Biomarkers in coronary artery disease: systematic review and meta-analysis
Nicola King1, Neil A Smart2, Theodore Bungon3
1School of Biomedical Sciences, Faculty of Health, University of Plymouth, Plymouth, Devon, UK.
Introduction:
Little information exists regarding the detection of early coronary heart disease protein biomarkers. The aim of this study was to investigate several potential candidates.
Methods:
Systematic review was carried out followed by meta-analysis.
Results:
The standardized mean difference (95% confidence intervals) for each comparison was: Troponins 2.31 (1.18, 3.4), iL-6 1.3 (0.8, 1.81), fibrinogen 1.55 (1.16, 1.94), NT-proBNP 1.05 (0.72, 1.38), lipoprotein a 0.75 (0.48, 1.03) osteoprotegerin 0.92 (0.23, 1.62), VCAM-1 1.53 (0.87, 2.18), pentraxin 3 0.87 (-0.13, 1.87), PAI-1 2.51 (-0.65, 5.66) MMP9 1.25 (0.36, 2.14), MCP-1 1.99 (1.12, 2.85) and adiponectin -1.11 (-1.49, -0.73).
Conclusion:
Multiple biomarkers that could potentially be used for the early detection of coronary heart disease were identified.
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